Heroes from two disparate publishers come together for three-on-three brawls in this continuation of the Marvel vs. Capcom tag-team fighting series. Projectile attacks, slams, jump kicks, punches, and over-the-top "hyper" combos are all possible with your choice of 32 characters. Representing Marvel are Iron Man, Deadpool, Storm, Magneto, Spider-Man, Captain America, Thor, Hulk, She-Hulk, Doctor Doom, Wolverine, Super-Skrull, X-23, Phoenix, M.O.D.O.K., and Dormammu.

Characters lifted from Capcom's vaults include Mike Haggar, Viewtiful Joe, Dante, Ryu, Morrigan, Chris Redfield, Felicia, Chun-Li, Trish, Amaterasu, Tron Bonne, Wesker, Nathan Spencer, Zero, Crimson Viper, and Arthur. A simple mode lets those new to the series perform combos with a single button press, while other difficulty settings require more intricate controls but rewards players with more attacks to choose from. Marvel vs. Capcom 3 also includes online support in a number of tournament-style play modes.