Mega Man ZX continues the incredible Mega Man X saga! It's been years since the wars between humans and Reploids. They now coexist peacefully, with humans using new Biometal technology to give them Reploid-like powers and Reploids giving up their immortality. When a mysterious group attacks three couriers delivering Model X and Model Z Biometals, they respond by fusing themselves with the Biometals, creating Model ZX! With powerful abilities at their disposal, they must discover who their enemies are and what they are after.

• Play as either a male character named Vent, or as a female named Aile -- Vent is bigger and more powerful, while Aile is smaller and more agile
• Biometal is the key - strategically attack bosses without damaging its Biometals, so Vent and Alie can absorb its power with no degradation
• Transformations offer a range of different abilities -- players can also transform into new Model X types like Model HX, Model LX and more
• Unlock additional areas of the map by using different Model X forms' powers
• Real time info system engages both screens of the DS system